Martha Connors is the wife of formor Oscorp scientist Curt Connors. She was originally scheduled to appear in The Amazing Spider-Man, but was cut from the final version of the film (similar to the Connors' son, Billy).
Not much is known of Martha, as she was not seen nor mentioned in the film and only mentioned in the video game.
When her husband became the Lizard, Martha feared for her life and kept herself and her son hidden away in her home. Once Connors was broken out of the Beloit Psychiatric Facility by Spider-Man, he went to go see his wife and son, but kept hidden away in the bushes of their backyard. Since then, Martha and her husband have not been even in the same proximity.