|Behind the scenes|
- "All these souls, lost and alone... I can save them, I can cure them! There's no need to stop me, Peter!"
- —Lizard to Spider-Man[src]
Lizard (Curt" Connors) is a former scientist at Oscorp Industries. He was Richard Parker's partner and colleague, and was working on the Lizard Serum with him. After Parker's death, Connors befriends his son, Peter.
The Lizard is a perfect example of science gone awry. One could blame Connors for creating the Lizard, but no one should blame him for the actions the Lizard does. When his reptilain mind takes over, Connors loses complete control and there only remains the savage, powerful, cross-species monstrosity known as the Lizard.
Some many years ago, Connors lost his right arm up to its elbow. As would be expected, this greatly affected him emotionally, and so Connors endeavored to find a "cure".
Dr. Connors soon came to be a scientist working at Oscorp Industries, and he met Richard Parker, a fellow employee, who wished to help Connors in his search for a cure. Though, the day that Richard and his wife, Mary, mysteriously went missing, Dr. Connors decided to totally shut down his work indefinitely. Years later, while working with some interns at Oscorp Tower, Curt Connors encountered Peter Parker, whom impressed him due to his knowledge beyond most teenagers. During this encounter, Connors did not find his name, but just thought him to be another intern.
A few days later, Peter came to Dr. Connors' house. Connors recognized Peter from the other day and, assuming he wanted an autograph, was quick to ask him to leave. However, Peter introduced himself as Richard Parker's son, and the scientist invited him in. They discussed the work that Peter's father and Dr. Connors were in, and why Connors had not approached the Parkers before. Peter proceeds to give the scientist his father's "decay rate algorithm", something he had been working on before his disappearance.
The following day, Peter met again with Dr. Connors in the scientist's laboratory. Peter proceeded to enter the decay rate algorithm in to a computer, with a hypothetical mouse being the target, but it fails to work at first. Peter continues to do it, finally getting a successful result that enables the mouse, named Fred, to grow an extra limb. Dr. Ratha approaches Connors, having seen the effects of Peter's decay rate algorithm, demanding that he starts human trials straight away, if they're to treat their dying employer. At first, Dr. Connors refuses to test people with the formula, causing him to be fired. Dr. Ratha decides to use the serum at a Veterans Administration hospital, under the guise of a flu shot. Connors, desperate to impress, injects the formula in to himself instead. Nothing happens immediately, and Curt falls asleep. When he awakes, his limb has fully regrown.
The scientist hears about Ratha's plan to inject the formula as a flu shot, and raced to intercept him. Along the way, Dr. Connors' arm, the one that regenerated, started to turn green and scaly. Just as he reaches the Williamsburg Bridge, he fully transforms in to a giant, mutated man-lizard hybrid. Unable to control his alter ego, Connors flips cars over the side of the bridge, the occupants only to be saved by Spider-Man.
The Lizard goes to the sewers, near to where Dr. Connors has constructed an underground lab. Spider-Man, having the suspicion that the Lizard is Dr. Connors himself, follows him. He proceeds to take a picture of the Lizard, via means of carefully-placed webs, but the camera is destroyed by the Lizard, not before he reads the camera's owner's name. Dr. Connors, as the Lizard, follows Peter Parker to his school. After ripping through the school to find him, the two finally engage in a battle. While Spider-Man's webs subdue the Lizard, they ultimately fail to do any harm.
After a quick battle, the Lizard runs through the streets of Manhattan. Aiming to reach Oscorp Tower, he finally gets there, having turned some police officers that subdued him in to lizard-men. The scientist-turned-lizard tries to get a machine that will release a toxic cloud, causing all humans to turn to a lizard-hybrid, like him. Gwen Stacy, his protégée, tries to stop him from taking it, but he wins over, not wanting to harm her.
Dr. Connors climbs to the top of Oscorp Tower, planning to release a gaseous cloud turning the human race in to lizard cross-species. Before he can do this, Spider-Man arrives. The two proceed to fight. George Stacy, captain of the police force, assists Spider-Man, knowing his true identity. Captain Stacy uses a shotgun to injure the Lizard, but this does next to nothing to the huge beast. Dr. Connors, not having control of his mind, stabs the cop with his claws.
Meanwhile, Spider-Man finally reaches the peak of the tower, and is able to replace the machine with an antidote to Connors' serum. Peter releases the cloud, causing the Lizard to turn back to an injured Dr. Connors, as well as changing the former police that became cross-species.
Following the ordeal, Dr. Connors is locked up in Beloit Psychiatric Hospital. He is visited by a mysterious man, seemingly familiar to the scientist. The man asks if Connors told Peter the truth about his father, but Curt demands Peter be left alone before the man mysteriously disappears.
After months at Beloit, Spider-Man appeared at the hospital with an odd proposition: Spidey would help Connors escape if Connors helped develop a serum to control the cross-species outbreak and save Gwen Stacy from infection. Connors agreed, sensing an opportunity for redemption. But he made Spider-Man promise not to let the dreaded Lizard resurface.
Spider-Man and Connors worked together to develop the serum. After their first try failed miserably, Spidey questioned Connors' true intentions. Suspicion turned into a tense confrontation, but Connors discovered a startling revelation: Spider-Man was the key to curing the outbreak. Connors used Spider-Man's DNA to create a new, improved serum. For the first time in a while, things were looking up for Curt Connors, but not for long.
Desperation forced him to make a terrible decision: he had no other choice but to transform into the Lizard one final time and use its strength to smash Alistaire Smythe's robot army. As the Lizard, Connors fought as Spider-Man's teammate. But after Smythe's defeat, the Lizard's reptilian brain clawed back in control. However, as a battle for the ages ensued, Spider-Man found the chance to inject the serum into Connors and revert him back to human form.
As promised, Spider-Man returned Connors to Beloit, with a newfound respect for this scientist who helped save Gwen and the people of New York. Today, Connors still wrestles with his inner demons, but his path to redemption has begun.
- In comics, Connors had a wife and son; his wife Martha died of cancer and he killed his son, Billy, as the Lizard. Before Billy died, he told his father that he always knew Connors would kill him. This is likely because Connors had transformed into the Lizard before in this comic as well, and had traumatized Billy.
- The darkened figure Connors saw in his cell late at night was credited as "Man in the shadows" in the film and has, currently, an unknown identity.
- Connors is one of five people who know Spider-Man's true identity; the others being Alistaire Smythe (deceased), George Stacy (deceased) and his daughter.